TABLE 2.

Antibacterial effect of standard formulation amoxicillin-clavulanate (875 mg of amoxicillin) on S. pneumoniae

Strain	Amoxicillin-clavulanate MIC (mg/liter)	Inoculum (log CFU/ml)	Log CFU/ml (mean ± SD)				T99(h)	T99.9(h)	AUBKC (log CFU/ml · h)
			Δ3	Δ6	Δ12	Δ24			0-12 h	0-24 h
05010S	3	6	−2.0 ± 0.2	−3.4 ± 0.2	−4.2 ± 0.1	−4.2 ± 0.1	4	6	15.4 ± 1.4	19.2 ± 1.9
		8	−1.2 ± 1.1	−3.0 ± 0.1	−5.3 ± 0.2	−6.0 ± 0.1	5	6	37.3 ± 0.6	41.6 ± 1.0
16001S	4	6	−1.7 ± 0.1	−3.0 ± 0.4	−4.1 ± 0.3	−4.4 ± 0.1	4	6	16.3 ± 1.6	23.3 ± 1.5
		8	−2.0 ± 0.3	−3.4 ± 0.1	−5.5 ± 0.1	−6.3 ± 0.2	3	6	33.4 ± 1.1	36.2 ± 1.2
30005S	5	6	−1.6 ± 0.2	−2.4 ± 0.1	−2.9 ± 0.1	−0.2 ± 0.1	4	7	21.8 ± 0.3	51.4 ± 0.5
		8	−1.2 ± 0.2	−3.7 ± 0.4	−3.9 ± 0.4	0 ± 0.2	5	5	40.4 ± 4.0	88.4 ± 0.5
047003S	6	6	−1.4 ± 0.1	−2.5 ± 0.1	−2.5 ± 1.2	−2.2 ± 1.6	5	18	24.1 ± 4.1	43.5 ± 19.4
		8	−0.8 ± 0.2	−2.0 ± 0.4	−2.5 ± 0.3	−2.9 ± 0.3	6	>24	53.1 ± 2.1	92.6 ± 5.0
05003S	8	6	0 ± 0.6	−0.2 ± 0.2	0.9 ± 0.2	2.2 ± 0.1	>24	>24	48.5 ± 2.3	115.3 ± 3.5
		8	−1.0 ± 0.4	−2.8 ± 0.2	−0.4 ± 0.1	0.1 ± 0.1	4	12	52.9 ± 1.7	122.9 ± 1.6
404053	8	6	−1.1 ± 0.4	−2.1 ± 0.4	−2.5 ± 0.1	−3.4 ± 0.1	7	24	27.4 ± 3.1	40.5 ± 2.9
		8	−0.4 ± 0.1	−1.6 ± 0.4	−2.5 ± 0.4	0.1 ± 0.3	7	>24	54.9 ± 2.8	112.4 ± 6.5