TABLE 3.

Antibacterial effect of pharmacokinetically enhanced (2,000 mg of amoxicillin) and standard formulation (875 mg of amoxicillin) on H. influenzae

Strain	Amoxicillin-clavulanate MIC (mg/liter)	Formulation	Inoculum (log CFU/ml)	Log CFU/ml (mean ± SD)				T99(h)	T99.9(h)	AUBKC (log CFU/ml · h)
				Δ3	Δ6	Δ12	Δ24			0-12 h	0-24 h
103-255	2	Enhanced	6	−0.8 ± 0.1	−1.9 ± 0.1	−4.2 ± 0.4	−4.4 ± 0.2	7	12	25.0 ± 1.8	29.1 ± 1.2
			8	−0.6 ± 0.1	−1.4 ± 0.1	−3.3 ± 0.1	−4.9 ± 0.2	12	12	54.0 ± 1.4	77.0 ± 2.7
643-119	5	Enhanced	6	−0.5 ± 0.1	−1.2 ± 0.1	−2.2 ± 0.3	−3.2 ± 0.4	12	24	33.9 ± 1.4	48.9 ± 5.1
			8	−0.5 ± 0.1	−1.1 ± 0.7	−3.0 ± 0.4	−5.2 ± 0.5	12	24	55.6 ± 2.3	78.0 ± 7.2
103-255	2	Standard	6	−0.6 ± 0.1	−1.4 ± 0.1	−3.2 ± 0.3	−4.0 ± 0.4	12	12	30.8 ± 2.3	36.6 ± 4.2
			8	−0.4 ± 0.1	−1.0 ± 0.2	−1.6 ± 0.2	−4.9 ± 0.2	24	24	61.0 ± 1.3	91.1 ± 3.4
643-119	5	Standard	6	−1.1 ± 0.1	−2.4 ± 0.1	−3.6 ± 0.3	−4.3 ± 0.1	5	12	22.9 ± 2.1	25.5 ± 3.1
			8	−0.3 ± 0.1	−0.8 ± 0.2	−1.1 ± 0.1	−2.5 ± 0.2	24	>24	63.9 ± 1.5	114.3 ± 3.5