TABLE 4.

Parameters fitted by E_max model of T > MIC to AUBKC24 and Δ24 for S. pneumoniae and H. influenzae at inocula of 10⁶ and 10⁸ CFU/ml (mean ± SD)

Species and relationship	Inoculum (log CFU/ml)	Emax	E0a	EC50	r
S. pneumoniae
T > MIC ∼ AUBKC24	6	107 ± 6	0.5 ± 21	21 ± 4	0.84
	8	125 ± 6	48 ± 11	22 ± 3	0.76
T > MIC ∼ Δ24	6	0.5 ± 0.4	−4.9 ± 1.6	22 ± 6	0.74
	8	−0.1 ± 0.5	−7.1 ± 2.0	28 ± 7	0.74
H. influenzae
T > MIC ∼ AUBKC24	6	128 ± 5	14 ± 1	30 ± 3	0.96
	8	142 ± 4	80 ± 2	28 ± 1	0.95
T > MIC ∼ Δ24	6	1.6 ± 0.6	−9.0 ± 15	37 ± 21	0.89
	8	−0.2 ± 0.3	−6.0 ± 0.5	32 ± 2	0.95

^aE0, the minimum value.