Table 3. HA and NA antibody responses induced by H7N9 and H1N1pdm09 vaccines in DBA/2J mice.

	HI Chicken a		HI Horse b		CPE-MN c		NAi b
Dose(μg HA)	GMT d (95% CI)	%SC e	GMT d (95% CI)	%SC e	GMT d (95% CI)	%SC e	GMT d (95% CI)	%SC e
H7N9
3.75	155 (97–246)	90	905 (293–2793)	100	520 (345–783)	100	226 (79–648)	90
0.75	29 (19–45)	55	139 (40–488)	70	117 (58–236)	80	57 (20–162)	60
0.15	15 (11–23)	16	80 (31–209)	78	32 (16–63)	42	16 (9–29)	30
0.03	11 (9–13)	5	15 (6–36)	11	11 (9–13)	5	10 (10–10)	0
0.006	10 (10–10)	0	10 (10–10)	0	10 (10–10)	0	10 (10–10)	0
0.001	10 (10–10)	0	10 (10–10)	0	10 (10–10)	0	10 (10–10)	0
Buffer	10 (10–10)	0	10 (10–10)	0	10 (10–10)	0	10 (10–10)	0
ED50	330 ng (193–570)		80 ng (36–173)		169 ng (102–279)		401 ng (177–970)
H1N1pdm09
3.75	355 (182–692)	95	n.d.	n.d.	184 (59–575)	90	172 (63–468)	90
0.75	178 (76–416)	85	n.d.	n.d.	61 (14–257)	70	40 (12–129)	50
0.15	37 (16–85)	40	n.d.	n.d.	12 (10–16)	30	23 (11–50)	30
0.03	10 (10–10)	0	n.d.	n.d.	10 (10–10)	0	10 (10–10)	0
0.006	10 (10–10)	0	n.d.	n.d.	10 (10–10)	0	10 (10–10)	0
0.001	10 (10–10)	0	n.d.	n.d.	10 (10–10)	0	10 (10–10)	0
Buffer	10 (10–10)	0	n.d.	n.d.	10 (10–10)	0	10 (10–10)	0
ED50	150 ng (100–226)		n.a.		401 ng (177–970)		347 ng (144–922)

^a20 animals per dose group for both vaccines.

^b10 animals per dose group for both vaccines.

^c20 animals per dose group for H7N9 vaccine; 10 animals per dose group for H1N1 pdm09 vaccine.

^dGeometric mean titer

^eSeroconversion (≥4-fold increase in antibody titer and antibody titer ≥ 1:40)

n.d., not done; n.a., not applicable.