Skip to main content
. Author manuscript; available in PMC: 2015 Feb 26.
Published in final edited form as: Aging Cell. 2011 Dec 28;11(2):192–202. doi: 10.1111/j.1474-9726.2011.00768.x

Figure 5.

Figure 5

Summary and a hypothetical model. Upon removal of the germline, DAF-16 localizes to the nuclei of intestinal cells. Together with DAF-12, this causes upregulation of fard-1 and lips-17, which may be involved in the production of a hypothetical lipophilic signal from the intestine to other tissues. DAF-16, PHI-62, and FTT-2 (or their orthologs in other species) have been shown to interact physically, and are all required for lifespan extension by germline ablation, suggesting the possibility that they may act together in this process. PHI-62 and TCER-1 are required for changes in some but not all DAF-16 target genes (Mark I didn’t think FTT-2 affected gene expression, so I changed this, right?)