Fig 3. When HIV RNA was detectable in CSF, constitutive CD8+IFNγ and IL-2 expression correlated positively with NCI (Fig. 3a) and CD4+ and CD8+CD107a expression correlated negatively with NCI (3b) Percent cytokine (3a) or lytic marker (3b) expression were plotted as a function of neurocognitive global deficit score (GDS).

Expression levels and GDS were square root transformed. a: When HIV RNA was detectable in CSF, there was a positive correlation between constitutive CSF CD8+IFNγ (solid line, diamonds r = 0.57, p = 0.004) and IL-2 expression (dotted line, circles r = .49, p = 0.01) and NCI. b: In contrast, CSF CD4+CD107a+ (solid line, triangles r = 0.49, p = 0.001) and CD8+CD107a (dotted line, circles r = .44, p = 0.004) expression were negatively associated with NCI.