Table 6. Longitudinal analysis confirms correlation between NC impairment and CD8+IFNγ+ (positive) and lytic activity (negative) at baseline and reveals positive association between NC impairment and residual HIV RNA in CSF at follow-up.
| Median (N = 16) | Baseline | Follow-up:6,16 | prt-Test p = |
|---|---|---|---|
| *GDS | 0.33 | 0.44 | 0.487 |
| HIV RNA CSF | 509 | 0 | 0.109 |
| % HIV RNA CSF>40 | 69% | 34% | .04 (FET) |
| HIV RNA PL | 9488 | 48 | 0.0004 |
| % HIV RNA PL>40 | 69% | 69% | NS |
| *CD163 CSF | 5.5 | 5.5 | 0.972 |
| CD4 | 385 | 465 | 0.299 |
| CD8% | 57 | 49 | 0.297 |
| CXCL10 CSF | 2891 | 1667 | 0.062 |
| * cCD8+IFNγ+% | 0.56 | 0.41 | 0.003 |
| * cCD8+Il-2+% | 1.20 | 0.43 | 0.041 |
| Regression (CSF) | r = | r = | Sig.ANOVA |
| GDS vs * cCD4+CD107a+ | -0.45 | -0.08 | 0.05, NS |
| GDS vs * cCD8+IFNγ+ | 0.70 | -0.05 | 0.01, NS |
| GDS vs * p24.CD4+IFNγ+ | -0.05 | -0.39 | NS, 0.03 |
| GDS vs * p24.CD4+TNFα+ | -0.15 | -0.42 | NS, 0.01 |
| GDS vs * HIV RNA CSF | .30 | .38 | NS, 0.02 |
c = constitutive
*square-root transformed