TABLE 1.
Inhibitory concentrations of cell inhibitors and antifungal compounds for aerobically and anaerobically grown C. albicans A72
| Compound | Inhibitory concn (μg/ml)a
|
|
|---|---|---|
| Aerobic growth | Anaerobic growth | |
| Amphotericin B | 0.5 | >20 (not reached) |
| Cerulenin | 1 | 4 |
| Terbinafine | 4 | 32 |
| Zaragozic acid B | 0.5 | 8 |
| Clotrimazole | 2 | >16 (not reached) |
| Fluconazole | 8 | >40 (not reached) |
| Miconazole | 4 | >16 (not reached) |
| Ketoconazole | 4 | >4 (not reached) |
a
Concentration at which no growth was evident after 48 h (aerobic) or 5 days (anaerobic). C. albicans A72 grown anaerobically appeared to be resistant to amphotericin B and the four azole antifungals, in that the cells still grew at the highest concentrations tested.