Mean (± SEM) number of Fos-IR nuclei activated in response to the elevated plus-maze test in different brain regions. N=6 per group. A: Nucleus accumbens (NA). Inset: Main effect of pups in the shell, *p = .036 (one-tailed test). B: Medial preoptic area (MPOA); no significant differences were detected. C: Amygdala (AMYG) - Interaction between reproductive experience and pup exposure in cortical AMYG and main effect of parity in medial AMYG. *p < .05. IR = immunoreactivity. Taken from Scanlan, V.F., Byrnes, E.M., Bridges, R.S., 2006. Reproductive experience and activation of maternal memory. Behavioral Neuroscience 120, 676–686, with permission.