Table 1.
Sociodemographic and clinical factors among people with radiographically confirmed OA of the knee by initiation of NSAIDs in year one (n= 1,846 persons)
| Baseline Characteristics | Initiate Any NSAID use (n=102) | Initiate Regular NSAID Use (n=55) | Non-users of any NSAID (n=1,744) |
|---|---|---|---|
| Percentage | |||
| Age (in years) | |||
| <65 | 55.9 | 50.9 | 54.6 |
| 65-74 | 35.3 | 38.2 | 33.8 |
| ≥75 | 8.8 | 10.9 | 11.6 |
| Women | 65.7 | 72.7 | 55.3 |
| Ethnicity/Race | |||
| Non-Hispanic White | 76.5 | 83.6 | 78.9 |
| Non-Hispanic Black | 19.6 | 12.7 | 18.1 |
| Other | 3.9 | 3.6 | 3.0 |
| Education | |||
| High school or less | 16.7 | 12.7 | 16.8 |
| Some college | 36.3 | 32.7 | 21.7 |
| College graduate | 12.8 | 9.1 | 22.9 |
| Graduate school | 34.3 | 45.5 | 38.7 |
| Income ($) | |||
| <25,000 | 19.6 | 16.4 | 14.1 |
| 25,000 - 50,000 | 22.6 | 20.0 | 27.1 |
| >50,000 | 57.8 | 63.6 | 58.8 |
| KL grade 3 or 4 | 45.1 | 41.8 | 38.6 |
| Multi-joint symptoms | 61.8 | 65.5 | 47.3 |
| Use of OTC NSAIDs or aspirin | 29.4 | 34.6 | 25.5 |
| Use of acetaminophen | 17.7 | 21.8 | 11.1 |
| Use of opioids | 7.8 | 10.9 | 3.4 |
| History of knee injury | 30.4 | 27.3 | 39.0 |
| History of knee surgery | 33.3 | 30.9 | 30.2 |
| Body Mass Index (kg/m2) | |||
| <25 | 10.8 | 14.6 | 18.8 |
| 25 - <30 | 37.3 | 43.6 | 39.1 |
| ≥30 | 52.0 | 41.8 | 42.2 |
| Knee alignment | |||
| Normal | 22.6 | 25.5 | 27.2 |
| Varus | 31.4 | 30.9 | 30.2 |
| Valgus | 46.1 | 43.6 | 42.7 |
| Proton pump inhibitor | 15.7 | 20.0 | 11.4 |
| Proton pump inhibitor/ histamine-2 receptor antagonist | 18.6 | 23.6 | 12.9 |
| Mean (standard deviation) | |||
| WOMAC Pain | 4.8 (4.2) | 4.9 (4.0) | 3.4 (3.7) |
| WOMAC Stiffness | 2.4 (1.8) | 2.4 (1.8) | 1.9 (1.7) |
| WOMAC Physical Function | 14.6 (13.1) | 15.5 (12.8) | 10.4 (11.6) |
| SF-12 Physical Component Score | 45.5 (10.3) | 44.7 (10.2) | 49.0 (8.7) |
| SF-12 Mental Component Score | 53.4 (8.5) | 53.2 (7.7) | 54.1 (7.6) |
| Joint space width (mm)* | 4.8 (1.0) | 4.7 (1.0) | 5.2 (1.2) |
*
Based on information on 1,116 participants included in analyses on JSW, among whom 60 initiated any NSAIDs use and 37 initiated regular NSAID use.