Figure 5.

ABCA1^−B/−B decreases AQP4 and IGF1 but increases MMP9 expression in the primary cultured astrocytes, decreases WT-PCN neurite-ougrowth cultured with the ABCA1^−B/−B astrocyte-conditioned-medium compared with the ABCA1^fl/fl astrocyte-conditioned-medium, which attenuated by IGF1-treatment after OGD. A, B: Western blot (A) and RT-qPCR data (B) in astroctyes. C, D: Neurite-outgrowth data in WT-PCNs (C), ABCA1^−B/−B and ABCA1^fl/fl PCNs (D).