. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: Eur Arch Psychiatry Clin Neurosci. 2014 Oct 9;265(2):137–145. doi: 10.1007/s00406-014-0550-4

Table 3.

Test statistics and p-values for the mixed models testing associations between CPLX2 variants and load-dependent working memory related neural activity in schizophrenia patients and healthy controls

SNP	SZ			SZ (Europ. descent)			HC			HC (Europ. Descent)
SNP	F	df	P	F	df	P	F	df	P	F	df	P
rs2443541	12.387^*	1, 104	0.001	5.278	1, 68	0.025	1.233	1, 122	0.269	3.127	1, 95	0.080
rs2243404	12.972^*	1, 104	< 0.001	5.349	1, 68	0.024	1.454	1, 122	0.230	3.274	1, 95	0.074
rs4242187	2.327	2, 104	0.103	0.535	2, 68	0.588	0.426	2, 122	0.654	1.380	2, 95	0.257
rs10072860	0.849	2, 104	0.431	0.802	2, 68	0.453	1.095	2, 122	0.338	2.212	2, 95	0.115
rs4868539	5.530^*	2, 104	0.005	1.638	2, 68	0.202	1.241	2, 122	0.293	1.981	2, 95	0.144
rs3892909	1.890	2, 103	0.156	2.388	2, 67	0.100	0.007	2, 122	0.993	0.201	2, 95	0.819
rs3822674	0.410	2, 104	0.665	0.012	2, 68	0.988	0.024	2, 122	0.976	0.661	2, 95	0.519

Single locus association analyses of working memory-related load-dependent neural activity (left and right DLPFC and left and right IPS) using mixed models and covarying for age, gender, scanner field strength and population stratification. Significant test statistics and p-values are displayed in bold face (p < 0.05) indicating differences between the genotype groups of each SNP.

p-value survives Bonferroni correction (p < 0.007; corrected for number of tested SNPs).

Additional models were carried out in healthy controls and in a subset of each participants group of European descent. SNP = single nucleotide polymorphism; SZ = patient with schizophrenia; HC = healthy control.