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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Ther Drug Monit. 2015 Apr;37(2):236–245. doi: 10.1097/FTD.0000000000000131

Table 4.

Estimated initial doses of busulfan by weight and age based on conventional dosing verses the model-based algorithm to achieve a targeted Css of 750ng/mL.1, 2

8kg
(6 months)		 10kg
(1 year)		 12kg
(2 years)		 20kg
(6 years)		 32kg
(10 years)		 50kg
(14 years)
Conventional dosing3
  Dose (mg) 8.7 10.7 9.8 16.5 25.5 40.8
  Dose (mg/kg) 1.1 1.1 0.8 0.8 0.8 0.8
Model-based algorithm3
  Dose (mg) 9.2 10.9 13.3 22.1 33.9 49.2
  Dose (mg/kg) 1.16 1.12 1.09 1.07 1.06 0.96
1

The target Css of 750ng/mL (range 600–900ng/mL) is equivalent to an AUC of 1098µM*min (range 900–1350µM*min).

2

Based on 50th percentile estimates of weight per age as provided by the World Health Organization (WHO) growth standards for infants and children.

3

Doses are based on achievement of the desired therapeutic Css over a 6-hour dosing interval.