Table 1.

Selected genes, functions and associated disorders.

Total SNPs	SNPs after exclusions	Gene Name	Full Gene Name	Chr.	Reported Processes and Functiona	Reported Associated Disordersb
18	12	FMO3	flavin containing monooxygenase 3	1q24.3	intrinsic to ER membrane, flavin adenine dinucleotide binding, monooxygenase activity, NADP binding	trimethylaminuria, metabolic disorder, familial adenomatous polyposis, polyposis, adenoma
10	7	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	2p22.2	angiogenesis, arachidonic acid and cellular aromatic compound metabolic process, endothelial cell migration and adhesion, epoxygenase and omega-hydroxylase activity, redox process, response to toxins, steroid and xenobiotic metabolism, visual perception, ER membrane, aromatase, monooxygenase, oxidoreductase and electron carrier activity, heme, oxygen and iron binding	breast cancer, congenital glaucoma tumors, cancer, glaucoma, prostate cancer, endometrial cancer, endometriosis, colorectal cancer, glaucoma open-angle
46	37	AOX1	aldehyde oxidase 1	2p33.1	aldehyde oxidase and electron carrier activity, metal ion and NAD binding	molybdenum cofactor deficiency, xanthinuria type I and II, tumors, genetic disorder, neurological disorders, renal disease, amyotrophic lateral sclerosis, influenza
7	3	UGT2B10	UDP glucuronosyltransferase 2 family, polypeptide B10	4q13.2	lipid metabolism, ER membrane, glucuronosyltransferase activity	none
17	15	AHR	aryl hydrocarbon receptor	7p21.1	apoptosis, blood vessel development, cell cycle, intracellular receptor signaling pathway, regulation of transcription from RNA polymerase II, prostate gland development, regulation of B-cell proliferation and transcription, response to stress and xenobiotics, xenobiotic metabolism, cytosolic AHR complex, DNA, transcription factor and protein binding	breast cancer, tumors, cancer, lung cancer, shock, adenocarcinoma lung, mammary tumor, retinoblastoma, inflammation, endometriosis
19	10	NAT1	N-acetyltransferase 1	8p22	small molecule and xenobiotic metabolism, cytosol, acetyltransferase activity	cancer, breast cancer, bladder cancer, colorectal cancer, polyps, tumors, lung cancer, prostate cancer, pancreatic cancer, colon cancer
15	14	NAT2	N-acetyltransferase 2	8p22	small molecule and xenobiotic metabolism, cytosol, acetyltransferase activity	bladder cancer, cancer, breast cancer, colorectal cancer, lung cancer, tumors, prostate cancer, polyps, colon cancer, endometriosis
1	0	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	15q24.1	9-cis-retinoic acid biosynthetic process, aging, amine, coumarin, insecticide, porphyrin and flavenoid metabolism, camera-type eye development, cell proliferation, dibenzo-p-dioxin catabolism, digestive tract development, embryo development, hepatocyte differentiation, hydrogen peroxide biosynthesis, parturition, antibiotic, food, herbicide, hyperoxia liposaccharide, nematode, organic cyclic compound, virus, vitamin A, wounding and arsenic response, demethylase, electron carrier, flavonoid 3'-monooxygenase and oxidoreductase activity, enzyme, heme and iron ion binding	lung cancer, breast cancer, cancer, tumors, prostate cancer, ahh inducibility, squamous cell carcinoma, oral cancer, colorectal cancer, breast carcinoma
7	2	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	19q13.2	coumarin metabolism and catabolism, exogenous drug, steroid, xenobiotic and small molecule metabolism, cytoplasm microtubule, ER membrane, coumarin 7-hydroxylase, oxidoreductase and electron carrier activity, enzyme, heme and iron ion binding	lung cancer, cancer, tumors, adenocarcinoma, smoking habit, liver diseases, colorectal cancer, adenoma, renal disease, carcinoma
30	13	CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	19q13.2	electron carrier, monooxygenase and oxidoreductase activity, heme and iron binding, incorporation or reduction of molecular oxygen	tumors, prostate cancer, cancer, inflammation, breast cancer, immunodeficiency, hypertrophy, virus infection, metastasis, necrosis
5	3	CYP2A13	cytochrome P450, family 2, subfamily A, polypeptide 13	19q13.2	xenobiotic and small molecule metabolism, ER membrane, aromatase and electron carrier activity, heme and iron binding	cancer, lung cancer
1	1	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	22q13.2	electron carrier and oxidoreductase activity, heme and iron binding, incorporation or reduction of molecular oxygen	breast cancer, Parkinson disease, schizophrenia, lung cancer, autoimmune hepatitis, cancer, hepatitis c, Alzheimer's disease, bladder cancer, tumors

^aObtained from Gene Ontoloqv website (www.qeneontoloqv.orq).

^bReported disease associations were obtained from the too 10 Novoseek disease relationships hits (number of articles in which both the qene's symbol or description and the disease appear) from GeneCards® (www.qenecards.orq).