Table 1. Consolidated Framework for Implementation Research (CFIR) domains and Lynch Syndrome screening implementation.

Main CFIR Domain	Potential Applications for Lynch Syndrome (LS) screening
Intervention characteristics (adaptability and complexity)	• Clinical decision support (CDS) for heritable colorectal cancer/LS screening, including potential computerized CDS
Outer setting (external policies and incentives/disincentives)	• Federal and state policies • Role and influence of accountable care organizations • Professional practice guidelines • Payer coverage of testing • External incentives (e.g., rewards for better patient outcomes)
Inner setting (structures and climate)	• If computerized CDS, Electronic Medical Record (EMR) software and informatics support, including training for users • Local institutional policy • Organizational climate • Communication patterns and willingness to collaborate across specialties
Characteristics of individuals (knowledge and beliefs about the intervention and role within the organization)	• Identification of key stakeholders across disciplines • Administrator buy-in and leadership • If an EMR-linked CDS, informatics buy-in and leadership • Pathologist engagement • Genetics knowledge of tool users/ordering physicians • Availability and proximity of personnel with genetics expertise • Patient input and needs, including advice on follow-through to improve prevention and family uptake outcomes
Process (planning and executing the intervention)	• Support for planning, testing, evaluation, and iterative improvements