. Author manuscript; available in PMC: 2016 Jan 15.

Published in final edited form as: Bioorg Med Chem Lett. 2014 Nov 22;25(2):302–306. doi: 10.1016/j.bmcl.2014.11.044

Table 2.

Comparative cytotoxicities for natural coibamide A and the [d-MeAla¹¹]-epimer of coibamide A against human lung carcinoma (H292), breast (MDA-MB-231), prostate (PC-3) and glioblastoma (SF-295) cancer cell lines.^a

cell line	IC₅₀ (nM)
cell line	coibamide A (natural product)	[d-MeAla¹¹]-coibamide A (synthetic product)
H292	124	610
MDA-MB-231	66	545
PC-3	80	424
SF-295	219	816

Concentration-response relationships were analyzed using Graphpad Prism Software, and IC₅₀ values were derived using nonlinear regression analysis fit to a logistic equation.