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. 2015 Feb 19;6:69–85. doi: 10.2147/JBM.S46256

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© 2015 Finotti et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Novel targets for γ-globin gene transcriptional activation.

Notes: Transcription factors directly or indirectly affecting (either positively or negatively) γ-globin gene transcription are listed, together with known regulatory microRNAs. High expression of miR-15a,¹⁵³ miR-16-1-1,¹⁵³ miR-486-3p,¹⁵⁵ miR-23a,¹⁵⁴ and miR27a¹⁵⁴ might lead to downregulation of repressors of γ-globin genes (MYB, BCL11A, KLF3, Sp1) and increased HbF production.

Abbreviation: LCR, locus control region; HbF, fetal hemoglobin; HbA, adult hemoglobin.