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Crystal Structure of HYPE
(A) Schematic diagram of domain organization of full-length human protein (top) and construct used for crystallization (bottom).
(B) Ribbon (left) and surface (right) representation of HYPE structure showing relative orientations of the TPR-motifs, linker, and FIC domain. ∗Pocket for cofactor binding in the FIC domain of the wild-type structure.
See also Figures S1–S3.
