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. 2004 Jul;24(14):6215–6230. doi: 10.1128/MCB.24.14.6215-6230.2004

FIG. 2.

FIG. 2.

Histone H2A C-tail SQE motif is important for survival in response to DNA damage. (A) Fivefold serial dilutions of wild-type and various histone H2A-AQE mutant S. pombe cells (hta1-S129A and/or hta2-S128A) were plated onto YES medium with the indicated concentrations of HU, MMS, or CPT. Pictures were taken after 4 days at 32°C. Strains used were hta1-S129A (TMN3294), hta2-S128A (TMN3295), hta1-S129A hta2-S128A (TMN3292 and TMN3293), and wild type (TMN2665). (B) Survival of wild-type and H2A-AQE mutant cells after exposure to the indicated doses of IR, UV, or incubation with 5 mU of bleomycin/ml for the indicated lengths of time. Strains used were wild type (TMN3296) and hta1-S129A hta2-S128A (TMN3293). Error bars indicate standard deviations from at least three experiments.