FIGURE 8.

Human β₂GPI-derived peptide sequences recognized by β₂GPI-reactive T cells share sequence identity with murine β₂GPI. Shown is a schematic representation of the full amino acid sequence of human β₂GPI (top) and the peptides (black boxes) recognized by T cells from human β₂GPI/LPS-immunized mice. The expanded regions show the amino acid sequences of epitopes in Domains I (peptide 7) and II (peptide 23) recognized by T cells from H-2^d- and H-2^b-bearing mice, respectively. Peptide 23 was also recognized by HLA-DRB1*0403-bearing human CD4⁺ T cell clones. Human β₂GPI-derived sequences for peptides 7 and 23 are aligned with the comparable sequences from murine β₂GPI to illustrate the percent identity between the sequences, with amino acid differences indicated by arrows.