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Genetic interaction of PI3K and S6K1 in the regulation of heart size. (A) S6K1 activity in NTg, dnPI3K transgenic (dnP), RRS6K1 (RR), and double transgenic (dnPI3K × RRS6K1 [dnP×RR]) mice. IP, immunoprecipitation; −, negative control (i.e., without antibody). (B) HW/BW ratios of dnPI3K, WTS6K1 (WT), RRS6K1, and double transgenic mice. *, P < 0.05 compared with NTg; #, P < 0.05 compared with WTS6K1 and RRS6K1. n was ≥5 in each group.
