TABLE 3.
Response of S6K knockout mice to chronic swimming traininga
| Mice | n | BW (g) | TL (mm) | HW (mg) | Normalized HW | HW/BW (mg/g) | HW/TL (mg/mm) | Normalized HW/BW |
|---|---|---|---|---|---|---|---|---|
| Wild type S6K+/+ | ||||||||
| Non-swim | 7 | 23.5 ± 1.2 | 16.5 ± 0.2 | 113.7 ± 8.0 | 1.00 ± 0.07 | 4.81 ± 0.13 | 6.86 ± 0.44 | 1.00 ± 0.03 |
| Swim | 5 | 23.4 ± 0.8 | 16.6 ± 0.1 | 144.7 ± 7.5^ | 1.27 ± 0.07^ | 6.18 ± 0.24^ | 8.72 ± 0.48^ | 1.29 ± 0.05^ |
| S6K1−/− | ||||||||
| Non-swim | 6 | 20.7 ± 0.7*⧣ | 15.6 ± 0.2*⧣ | 95.9 ± 4.0*⧣ | 1.00 ± 0.04 | 4.64 ± 0.15 | 6.13 ± 0.25 | 0.97 ± 0.03 |
| Swim | 8 | 20.2 ± 0.7*⧣ | 15.8 ± 0.1*⧣ | 115.9 ± 4.1^ | 1.21 ± 0.04^ | 5.75 ± 0.17^ | 7.34 ± 0.25^+ | 1.20 ± 0.04^ |
| S6K2−/− | ||||||||
| Non-swim | 5 | 28.0 ± 1.2* | 16.5 ± 0.1 | 118.3 ± 2.0 | 1.00 ± 0.02 | 4.25 ± 0.15 | 7.17 ± 0.10 | 0.88 ± 0.03 |
| Swim | 6 | 24.7 ± 0.7 | 16.4 ± 0.1 | 136.7 ± 4.1^ | 1.16 ± 0.03^ | 5.56 ± 0.21^+ | 8.32 ± 0.25^ | 1.16 ± 0.04^+ |
| S6K1−/− S6K2−/− | ||||||||
| Non-swim | 3 | 20.8 ± 1.5⧣ | 15.2 ± 0.3*⧣ | 89.2 ± 2.8*⧣ | 1.00 ± 0.03 | 4.32 ± 0.28 | 5.87 ± 0.24 | 0.90 ± 0.06 |
| Swim | 2 | 19.7 ± 0.4*⧣ | 15.1 ± 0.2*⧣ | 118.6 ± 6.9^ | 1.33 ± 0.08^ | 6.03 ± 0.22^ | 7.85 ± 0.38^ | 1.25 ± 0.05^ |
a
Results are presented as means ± standard errors of the mean. TL, tibia length. Normalized HW, heart weights of swimming mice were normalized to those of nonswimming mice of the same genotype. Normalized HW/BW, HW/BW ratios of all groups were normalized to that of nonswimming wild-type S6K+/+ mice. *, P < 0.05 compared to S6K+/+ non-swim; ⧣, P < 0.05 compared to S6K2−/− non-swim; ^, P < 0.05 compared to non-swim mice in same group; +, P < 0.05 compared to S6K+/+ swim group.