FIGURE 1.
GLP-1 potencies toward GLP1R chimeric receptors. A, the GLP-1 potency of the wild-type and chimeric GLP1Rs with the sequence from ECL3 to C terminus of GIPR (GL/I6) or of VPAC1R (G/V[E3-C]). B, schematic diagram for chimeric receptors and log EC50 values of GLP-1. Amino acid sequences of ECL3 of GLP1R, GIPR, and VPAC1R were aligned above the receptor structures. The conserved residues between GLP1R and GIPR are indicated as red dots. The data on the sigmoidal curves and log EC50 values represent the means ± S.E. of at least three independent experiments with triplicates. a, versus wild-type GLP1R (p < 0.05).