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Mutation of GLP-1-interacting residues in the second half of GLP1R ECL3. A, sigmoidal curves of GLP-1-induced receptor activation. Amino acid residues Leu379, Arg380, Phe381, or Leu384 in ECL3 were mutated to either basic or acidic residues. B, the log EC50 values of mutant receptors. The data on the sigmoidal curves and EC50 values are presented as the means ± S.E. of at least three independent experiments. a, versus wild-type GLP1R (p < 0.05).
