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Effect of GLP-1 complementary mutation on the R380D GLP1R mutant. A, ligand potency of mutant GLP-1s in which Gky4 and Asp9 were replaced with basic residues, toward wild-type GLP1R. B, ligand potency of mutant GLP-1 peptides toward the R380D mutant. C, binding analysis of wild-type and [Arg9]GLP-1 peptides to GLP1R. D, ligand binding affinity of GLP-1 complementary mutation to mutant R380D. The results are presented as the means ± S.E. of at least three independent experiments.
