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. 2015 Jan 12;290(9):5797–5809. doi: 10.1074/jbc.M114.625350

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Rb1^+/−;p27^T187A/T187A mice do not develop pituitary tumors. A, representative coronal sections of mouse pituitaries were stained with H&E. The three pituitary lobes are marked. PL, posterior lobe; IL, intermediate lobe; AL, anterior lobe. Rb1^+/− mice at 6 months of age (n = 5) contained one to two IL tumors as marked by black arrows, while Rb1^+/−,p27^T187A/T187A mice at 9 months of age (n = 5) contained pituitaries identical to those in WT and p27^T187A/T187A mice. B, representative p27 IHC sections showing low level staining in WT, Rb1^+/−, p27^T187A/T187A, and Rb1^+/−;p27^T187A/T187A IL, under the H&E images of the same genotypes. C, in the same experiment, POMC-Cre;Rb1^lox/lox;Trp53^lox/lox;Skp2^−/− IL showed robust p27 staining. Scale bars, 100 μm.