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14-oxoDHA inhibits NF-κB-derived cytokine mRNA expression. Primary alveolar macrophages were treated with 100 ng/ml LPS, 100 ng/ml LPS, and 10 μm 14-HDoHE or 100 ng/ml LPS and 10 μm 14-oxoDHA for 6 h. LPS induced cytokine mRNA expression, which was abrogated by 14-oxoDHA for TNFα (A), IL-6 (B), and IL-1β (C). ** p ≤ 0.01. 14-HDoHE treatment resulted in a significant inhibition of IL-6.
