FIGURE 1.

Transmission electronic microscopy image of the primary stock solution of AgNP₁₅ and behavior of the nanoparticle under different concentrations in culture medium evaluated by DLS analysis. A, a sample of the solution stock from the manufacturer was used for characterization by transmission electronic microscopy illustrating that the suspension was relatively homogeneous with the majority of AgNP with a diameter close to 15 nm, but also that other particles had different ratios between smaller and larger diameters. B, representative data obtained by DLS analysis performed at 37 °C with a concentration of 1, 5, 10, or 25 μg/ml AgNP₁₅ in RPMI 1640 supplemented with 10% FBS, the experimental conditions used in this study. Data are from one representative experiment out of three.