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. 2015 Feb;212(2):199.e1–199.e24. doi: 10.1016/j.ajog.2014.08.005

Table 2.

Interim Venice assessments of epidemiological credibility for each metaanalysis

Gene SNP Phenotype Studies, n Sample with minor allelea Pooled OR I2 % Deviation from HWEb Proteus effect Harbord test P value Funnel plot Genotyping QC Risk of population stratification Venice rating Overall credibility
ADRB3 rs4994 OAB 2 136 2.46 0.0 None None n/a n/a Not reported Yes38c BBB Moderate
COL1A1 rs1800012 SUI 2 92 2.09 0.0 Yes46 None n/a n/a Not reported Low CBC Weak
POP 4 249 1.33 0.0 None None .88 Symmetric Not reported Yes41,42c BBB Moderate
COL3A1 rs1800255 POP 2 257 1.19 0.0 None Yes n/a n/a Not reported49/appropriate50 None BCB Weak
rs111929073 POP 2 115 0.56 83.7 None None n/a n/a Not reported Yes52c BCB Weak
LAMC1 rs10911193 POP 4 218 1.12 0.0 None None .97 Symmetric Appropriate54,55/not reported56 Low BCB Weak
rs20563 POP 3 525 1.12 0.0 None None .86 Symmetric Appropriate Low BCA Weak
rs20558 POP 3 551 1.12 0.0 None None .93 Symmetric Appropriate Low BCA Weak
MMP1 rs1799750 POP 2 234 0.83 74.9 Yes61 Yes n/a n/a Not reported Low BCC Weak
SUI 2 150 0.88 3.4 None None n/a n/a Not reported Yes60c BCC Weak
MMP3 rs3025058 POP 2 381 1.11 0.0 Yes61 None n/a n/a Not reported Low BCC Weak
MMP9 rs3918242 POP 2 99 1.25 0.0 None None n/a n/a Not reported Low CCC Weak
rs17576 POP 3 473 1.05 68.9 None None .72 Symmetric Not reported57/appropriate54 Low BCB Weak

Three-letter code corresponds to A through C ratings of amount of evidence, its consistency, and its protection from bias (Supplementary Figure).

HWE, Hardy Weinberg Equilibrium; OAB, overactive bladder; OR, odds ratio; POP, pelvic organ prolapse; QC, quality control; SNP, single-nucleotide polymorphism; SUI, stress urinary incontinence.

Cartwright. Genetic association studies of LUTS and POP. Am J Obstet Gynecol 2015.

a

Pooled sample size of participants with minor allele

b

Checked in controls and whole population, and metaanalysis rechecked excluding studies with significant departure

c

Studies each include populations with mixed descent groups without reported adjustment.