Supplementary Table 2.
Overrepresented Gene Ontology biological processes among investigated genes
| Biological process | GO term | Description | Genes |
|---|---|---|---|
| 1 | GO:0030574 | Collagen catabolic process | MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP11 |
| 2 | GO:0005578 | Proteinaceous extracellular matrix | LOXL1 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP11 TIMP1 |
| 3 | GO:0006508 | Proteolysis | CPE MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP11 PRCP |
| 4 | GO:0008152 | Metabolic process | CPE GSTM1 MMP2 MMP8 MMP3 GSTP1 MMP1 MMP10 MMP9 |
| 5 | GO:0005576 | Extracellular region | COL1A1 COL3A1 CPE EDN1 ESR2 LAMC1 LOXL1 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP11 TIMP1 COL18A1 |
| 6 | GO:0007267 | Cell-cell signalling | PGR AR ADRA1A ESR2 EDN1 |
| 7 | GO:0005615 | Extracellular space | AR COL1A1 COL3A1 EDN1 LAMC1 LOXL1 MMP2 MMP3 MMP8 MMP9 MMP10 COL18A1 |
| 8 | GO:0008270 | Zinc ion binding | ESR1 ESR2 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP11 PGR ZFAT |
All processes significant at P < .01, analysis using http://webclu.bio.wzw.tum.de/profcom/. Overrepresented Gene Ontology: http://www.geneontology.org.
Cartwright. Genetic association studies of LUTS and POP. Am J Obstet Gynecol 2015.