Table 1.

Clinical data

					ALSFR-S		Muscular testing
Patient	Onset	Duration (months)	El Escorial criteria	Atrophy	Total (/48)	Hand (/4)	Total (/150)	UL (/45)	Hand (/10)
1.M.68	UL	74	Probable	+	42	1	148	43	8
2.M.50	UL	28	Probable	+	42	1	145	40	5
3.M.54	LL	28	Probable	+	41	4	120	41	8
4.M.59	LL	24	Probable	+	34	3	102	39	7
5.M.62	B	12	Probable	+	43	3	147	44	9
6.M.48	UL	23	Probable	+	39	2	145	42	8
7.M.61	LL	33	Probable	+	39	4	105	43	8
8.M.44	LL	21	Probable	−	40	4	131	44	9
9.F.76	LL	26	Lab-supported	−	34	4	105	41	8
10.M.66	UL	34	Probable	+	37	2	144	41	6
11.M.45	B	15	Definite	+	31	1	137	41	8
12.M.55	LL	58	Probable	+	30	2	79	38	6
13.F.37	UL	39	Probable	+	41	3	140	39	6
14.M.51	UL	10	Probable	+	45	4	134	43	8
15.M.52	UL	15	Lab-supported	+	46	4	145	40	8
16.F.50	UL	14	Probable	+	44	4	145	44	9
17.F.56	UL	15	Probable	+	40	3	144	42	7
18.M.58	LL	43	Probable	+	33	3	114	42	8
19.F.62	LL	8	Probable	−	40	3	145	42	8
20.M.65	UL	17	Probable	+	45	3	145	40	8
21.M.63	LL	19	Lab-supported	+	40	3	129	43	8

Patient: rank.gender (F, female; M, male).age (years old); Onset: first clinical signs manifested in upper limb (UL) or lower limb (LL) or bulbar (B); Duration of the disease in months; El Escorial criteria for amyotrophic lateral sclerosis (ALS): definite ALS (Definite), clinically probable ALS (Probable), Clinically probable—laboratory supported ALS (Lab-supported); Atrophy observed (+) or not (−) on the side explored during the electrophysiological investigations; ALSFR-S: total score of the revised ALS functional resting scale (Total/maximal score 48) and for handwriting (Hand/4); Muscular testing: in upper and lower limbs and in the neck (Total/150), on the side explored during the electrophysiological investigations (UL/45) and in intrinsic hand muscles (Hand/10).