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Schematic representation illustrates that JMJD3 cooperates with RUNX2 to regulate proliferation and hypertrophy of chondrocytes. (A) H3K27me3 modification maintains the transcription repression of RUNX2 target gene Runx2 and Ihh in chondrocytes. (B) JMJD3 erases the H3K27me3 modification and facilitates RUNX2 to regulate the transcription of Runx2 and Ihh in chondrocytes.
