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. 2014 Jul 31;211(2):187–196. doi: 10.1093/infdis/jiu424

Figure 5.

Figure 5.

Cord blood mononuclear cells (CBMCs) primed with cytomegalovirus (CMV) upregulate CCR5 expression on CD4+ T central memory (TCM) cells. A, Naive T (TN) cell (N; CD45RO−CD27+) and TCM cell (CM; CD45RO+CD27+) subsets were analyzed among CD3+CD4+ CBMCs cocultured for 4 days with CMV-infected macrophages, uninfected macrophages (control), or phytohemagglutinin (PHA)/interleukin 2 (IL-2). Data shown are dot plots of 1 representative donor of 8. B, The fraction of CD4+ TN and TCM CBMCs that express CCR5 was determined over time after coculture with CMV-infected macrophages (▴), uninfected macrophages (control; •), or PHA/IL-2 (X). Data shown are expressed as the mean ± standard error of samples from 8 individual donors. *P < .001, compared with control CBMCs at the corresponding time point.