Skip to main content
. 2015 Feb 2;9(2):1236–1249. doi: 10.1021/nn504905q

Figure 5.

Figure 5

Local brain delivery of PBAE/GFP Nanoparticle via CED leads to effective tumor transfection in vivo. Coronal section of a 9L tumor bearing rat brain at 7 days post PBAE/GFP infusion showing the tumor region (A, scale bar = 2 mm). Fluorescence microscopy images show GFP+ transfected cells in the tumor area (B, scale bar = 2 mm). Enlarged area shows a wide distribution of GFP+ cells within the entire tumor area including the periphery (C, scale bar = 500 μm). The colocalization of GFP and Cy5 shows that the nanoparticles penetrate into the cells and successfully transfect them (D–F, scale bar: 50 μm). Re,: Cy5; green, GFP; blue, DAPI.