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. 2014 Dec 22;17(3):254–260. doi: 10.1111/dom.12415

Figure 1.

Figure 1

Designs of the (A) Japanese and (B) European studies. (A) Day (D); D-1, evening before D1 visit and insulin glargine 300 U/ml (Gla-300) or insulin glargine 100 U/ml (Gla-100) administration; D1, Gla-100 0.4 U/kg, Gla-300 0.4 U/kg or Gla-300 0.6 U/kg administered at approximately 10:00 h (14:00 h at latest) after adjustment for blood glucose during preclamp; D2, end of clamp. The study comprised three treatments (Gla-100 0.4 U/kg, Gla-300 0.4 U/kg and Gla-300 0.6 U/kg), three treatment periods (periods 1–3) and three sequences. (B) D1, Gla-100 0.4 U/kg, Gla-300 0.4 U/kg, Gla-300 0.6 U/kg or Gla-300 0.9 U/kg administered at approximately 09:00 h (14:00 h at latest) after adjustment for blood glucose during preclamp. The clamp was maintained for 36 h after dosing. The study comprised four treatments (Gla-100 0.4 U/kg, Gla-300 0.4 U/kg, Gla-300 0.6 U/kg and Gla-300 0.9 U/kg), four treatment periods (periods 1–4) and four sequences.