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Serum insulin glargine concentration (INS), glucose infusion rate (GIR) and blood glucose profiles after a single dose in the European study. (A) Median INS profiles (linear scale) with lower limit of quantification (LLOQ) of 5.02 µU/ml; (B) mean smoothed [locally weighted regression in smoothing scatterplots (LOESS) factor 0.15] 36-h body-weight-standardized GIR profiles; (C) mean smoothed (LOESS factor 0.15) 36-h blood glucose profiles.
