Table 2.
(A) | Gla-100 0.4 U/kg | Gla-300 0.4 U/kg | Gla-300 0.6 U/kg |
---|---|---|---|
Number | 18 | 18 | 18 |
Mean ± s.d. GIR-AUC0–36, mg/kg | 1859 ± 1085 | 990 ± 1233† | 1591 ± 1719† |
Mean ± s.d. GIRmax, mg/kg/min* | 2.2 ± 0.8 | 1.2 ± 1.0† | 1.8 ± 1.3† |
Median (interquartile range) T50%-GIR-AUC0–36, h | 13 (10–15) | 17 (14–21)‡§ | 18 (15–21)‡ |
(B) | Gla-100 0.4 U/kg | Gla-300 0.4 U/kg | Gla-300 0.6 U/kg | Gla-300 0.9 U/kg |
---|---|---|---|---|
Number | 22 | 22** | 22†† | 22 |
Mean ± s.d. GIR-AUC0–24, mg/kg | 1480 ± 810 | 383 ± 379† | 728 ± 779† | 1179 ± 608 |
Mean ± s.d. GIR-AUC0–36, mg/kg | 1725 ± 920 | 631 ± 590† | 1118 ± 1018† | 1845 ± 765 |
Mean ± s.d. GIRmax, mg/kg/min* | 2.2 ± 0.9 | 1.6 ± 1.1† | 1.5 ± 0.9 | 2.2 ± 0.7 |
Median (interquartile range) T50%-GIR-AUC0–36, h | 12 (11–13) | 17 (12–24)‡ | 17 (14–23)‡ | 19 (18–22)‡ |
Median (interquartile range) T50%-GIR-AUC0–24, h | 11 (10–12) | 11 (8–14) | 13 (11–13) | 13 (12–15) |
GIR, glucose infusion rate; GIR-AUC0–24/36, area under the body-weight-standardized GIR time curve from time 0 to 24 or 36 h; GIRmax, maximum smoothed body-weight-standardized GIR; T50%-GIR-AUC0–36, time to 50% of GIR-AUC0–36; s.d., standard deviation.
LOESS smoothing factor of 0.06.
Statistically significantly different from insulin glargine 100 U/ml 0.4 U/kg: concluded if p-value <0.05.
Statistically significantly different from insulin glargine 100 U/ml 0.4 U/kg: for T50%-GIR-AUC0–36, concluded if p-value <0.1. No inferential analysis was performed for T50%-GIR-AUC0–24.
N = 14 (4 of 18 subjects with no GIR were excluded).
Three of 22 subjects received rescue insulin, after which GIR was set to ‘missing’.
Two of 22 subjects received rescue insulin, after which GIR was set to ‘missing’.