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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Nature. 2014 Nov 2;517(7535):501–504. doi: 10.1038/nature13868

Extended Data Figure 1. GaMD immunization of γ1- mice induces renal dysfunction and glomerular deposition of PAS+ material that includes IgG and complement.

Extended Data Figure 1

a, WT and γ1- mice (4/gp) were immunized with GaMD. Urine LE and blood were obtained. b, Representative photomicrographs of glomeruli stained for C3 (top panels) or total mouse IgG (bottom panels) from WT (right panels) and γ1-/- mice (left panels) 12 d post-GaMD immunization 3 mice/group. c, Deposition of amorphous PAS+ material in glomeruli of γ1-, but not WT begins ∼7 days post GaMD-immunization and leads to glomerular destruction by day 9. Note the scarcity of inflammatory cells in glomeruli. Representative data of 6 mice/group.