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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Nature. 2014 Nov 2;517(7535):501–504. doi: 10.1038/nature13868

Figure 1. GaMD-immunized γ1- mice develop lethal glomerulopathy.

Figure 1

WT and γ1- mice (4/gp, a-g: 8 or10/gp, h) were immunized with GaMD. a, Urine protein. b, Serum BUN and albumin. c-g, Representative photographs of mice 13 d after GaMD immunization demonstrate anasarca (c and d), ascites (e), kidney hypoperfusion (f) and glomerulopathy (g) with PAS+ deposits and fibrosis (blue color on Masson's stain) only in γ1- mice. h, Survival curves. All figures show means ± SEMs. Experiments depicted in all figures were repeated with similar results unless otherwise indicated. * p<0.05. p values were calculated with a non-parametric Mann-Whitney 2-tailed t test for all data shown in all figures.