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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Nature. 2014 Nov 2;517(7535):501–504. doi: 10.1038/nature13868

Figure 2. Glomerulopathy in GaMD-immunized γ1- mice is complement- and FcRγ -independent and associated with IgG3 cryoglobulinemia.

Figure 2

a. Serum anti-goat IgG titers in WT and γ1- mice (4/gp) 8d after GaMD immunization. b, c. Urine protein (b) and BUN (c) of GaMD-immunized γ1-, γ1-/FcRγ-, γ1-/C3-, C3-/ FcRγ- and γ1-/C3-/FcγR- mice (5/gp). d, e. Serum cryoprecipitate protein and Ig isotype concentrations 6-7 d after GaMD immunization of WT and γ1- mice (7 or 8/gp). Only cryoprecipitates from γ1- mice contained detectable Ig. f. IgG3 (brown color) in glomerular capillaries (arrows) of γ1- mice 8d after GaMD (panels 1, low magnification; panel 2, high magnification). * p<0.05, **p<0.005. ND = none detected.