Extended Data Figure 8. GaMD-immunized γ1^+/- mice generate large IgG3 responses but develop mild renal disease.

BALB/c mice homozygous (γ1^+/+), heterozygous (γ1^+/-) and null (γ1^-/-) for a functional γ1 allele (6/gp) were injected s.c. with GaMD. a, Sera were titered for goat IgG-specific IgG1, IgG2a and IgG3 0, 8 and 12 days later. Day 0 titers were zero for all Ig isotypes (data not shown). b, Urine samples from the same mice were assayed for protein and leukocyte esterase. ND = none detected.