Table 1.
Patient demographics and clinical characteristics of patients categorized as low or high ketone before administration of l-carnitine or placebo
| Variable | Low Ketones (n = 15) | High Ketones (n = 15) | P Value |
|---|---|---|---|
| Age, yr (IQR) | 60 (52, 68) | 69 (60, 74) | 0.096 |
| Race, n (%) | |||
| White | 11 (73.33) | 13 (86.67) | 0.410 |
| African American | 4 (26.67) | 2 (13) | |
| Male, n (%) | 12 (80) | 9 (60) | 0.268 |
| Comorbidities, n (%) | |||
| Coronary artery disease | 5 (33) | 2 (13) | 0.235 |
| Congestive heart failure | 2 (13) | 4 (27) | 0.410 |
| COPD | 4 (27) | 4 (27) | 0.999 |
| DNR | 0 (0) | 0 (0) | 0.999 |
| Hypertension | 10 (67) | 11 (73) | 0.714 |
| Diabetes | 4 (27) | 6 (40) | 0.473 |
| Chronic renal insufficiency | 2 (13) | 4 (27) | 0.410 |
| Baseline laboratory values (IQR) | |||
| Platelets, cells/mm3 | 159 (82, 232) | 196 (158, 335) | 0.280 |
| Creatinine, mg/dl | 1.8 (1.4, 2.4) | 1.7 (1.5, 2.7) | 0.945 |
| Total bilirubin, mg/dl | 2.1 (0.6, 3.1) | 1.2 (0.9, 1.9) | 1.000 |
| Lactate, mmol/L | 2.9 (2.2, 5.1) | 1.9 (1.6, 4.0) | 0.085 |
| SOFA, score (IQR) | 10 (9, 14) | 12.5 (8, 14) | 0.871 |
Definition of abbreviations: COPD = chronic obstructive pulmonary disease; DNR = Do Not Resuscitate order; SOFA = Sequential Organ Failure Assessment.
Note: Data represent medians and interquartile ranges (IQRs) or absolute numbers with percentages (%), as appropriate.