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. 2015 Feb 22;14:52. doi: 10.1186/s12943-015-0323-3

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© Kang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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YAP1 is a target of miR-15a and miR-16-1 in GAC. (A) The miR-15a and miR-16-1 binding sites in YAP1 3′UTR as TargetScan predicted (www.targetscan.org). (B) The YAP1 mRNA expression after ectopic miR-15a and miR-16-1 expression in AGS, MKN1, MGC-803 and NCI-N87 cells (**, P < 0.001). (C) miR-15a and miR-16-1 transfection down-regulated YAP1 protein expression in GAC cells. (D) miR-15a and miR-16-1 suppressed the luciferase activities in the constructs containing wild-type binding sites in YAP1 3′UTR, but for the constructs containing the deletion binding sites, miR-15a and miR-16-1 had no suppressive effect on the luciferase activities. (E1) miR-15a showed negative correlation with YAP1 protein expression (P = 0.048). (E2) miR-16-1 expression was negatively correlated with YAP1 protein expression (P = 0.010).