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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Mutat Res. 2015 Feb 1;772:55–62. doi: 10.1016/j.mrfmmm.2015.01.002

Figure 4. Integrative genomics viewer (IGV) images comparing specific mutations present in both exome and transcriptome from the same single cell.

Figure 4

The genetic background is defined by the unamplified control (Unamp). (A) The presence of a germline SNV in mRNAs. (B) The presence of a heterozygous somatic A:T transversion, a signature ENU-induced mutation, in mRNAs. (C) A heterozygous somatic SNV absent from mRNAs. (D) A somatic C to A transversion generating a nonsense mutation; no mutant transcript detected. (E) A heterogyzous bi-nucleotidyl CG-deletion absent from mRNAs. (F) The binucleotidyl deletion induces a premature TAG (CTA in the illustration; Sfi1 gene is transcribed in reversed order) stop codon (red arrows) in a downstream exon.