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. 2014 Dec 17;16(6):508. doi: 10.1186/s13075-014-0508-y

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© Leong et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Epigallocatechin 3-gallate administration slows progression in early and midstage osteoarthritis in mice that underwent surgical destabilization of the medial meniscus. Mice underwent sham surgery or surgical destabilization of the medial meniscus (DMM), and cartilage specimens were treated with vehicle or epigallocatechin 3-gallate (EGCG). Safranin O stains and Osteoarthritis Research Society International (OARSI) scores of mice at 4 weeks (A and B) and 8 weeks (C and D) following surgery are shown (*P < 0.05 by analysis of variance; n = 6/group). Arrowheads indicate the areas of cartilage fibrillation or erosion, and arrows indicate loss of Safranin O staining.