Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jan 30;17(1):13. doi: 10.1186/s13058-015-0515-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Vilquin et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

MicroRNA-125b is a poor prognostic biomarker and represents a therapeutic target to overcome letrozole resistance. (A) Kaplan-Meier analysis (log-rank test) for relapse-free survival (RFS) is shown in a cohort of primary breast tumor samples (n = 65). (B) Effect of the microRNA (miR) miR-125b-5p expression level and lymph node status signature on RFS among our cohort with 65 breast tumors. (C) Cell viability in response to letrozole in Res-Let cells transiently transfected with either miR-125b-5p inhibitor or its negative control. (D) Cell viability in response to letrozole (10⁻⁵ M) and/or MK-2206 (10⁻⁹ M) in MCF-7aro cells transiently transfected with either miR-125b-5p mimic or its negative control. (C) and (D) are representative of at least three independent experiments. ***P < 0.001 (Student’s t-test).