Table 1.
Deregulated microRNA expression associated with resistance to aromatase inhibitors
| miRNA probe sets a | Fold change b | |||
|---|---|---|---|---|
| Res-Let | Res-Ana | |||
| Replicate 1 | Replicate 2 | Replicate 1 | Replicate 2 | |
| miR-125b | 1.87 | 2.44 | 1.86 | 2.13 |
| miR-205 | 2.76 | 2.86 | 2.19 | 2.99 |
| miR-30a | 1.71 | 3.17 | 2.97 | 2.15 |
| miR-424 | −2.33 | −2.07 | −1.76 | −1.74 |
| miR-1292 | −3.02 | −1.73 | −2.06 | −2.06 |
| miR-4492 | −2.51 | −1.77 | −2.14 | −2.02 |
| miR-21 | 1.73 | 1.70 | NC | NC |
| miR-125b-2 | 1.70 | 1.79 | 1.94 | NC |
| miR-128-1/miR-128-2 | 1.70 | 1.70 | NC | NC |
| miR-146b | 1.96 | 1.97 | 1.78 | NC |
| miR-301a | 1.80 | 2.63 | NC | NC |
| miR-494 | 3.14 | 1.70 | NC | NC |
| miR-501 | 2.28 | 2.46 | NC | NC |
| miR-1226 | 2.28 | 1.98 | NC | NC |
| miR-1247 | 2.09 | 3.85 | 2.20 | NC |
| miR-3135b | 1.98 | 1.81 | NC | NC |
| miR-3613 | 2.68 | 1.93 | 2.76 | NC |
| miR-4667 | 1.91 | 2.30 | 1.91 | NC |
| miR-23a | −1.75 | −2.24 | NC | NC |
| miR-23b | −2.08 | −1.98 | −1.72 | NC |
| miR-92a-1 | −1.73 | −2.55 | NC | −1.86 |
| miR-193a | −2.03 | −1.82 | NC | NC |
| miR-193b | −2.04 | −2.07 | NC | NC |
| miR-324 | −1.88 | −1.85 | NC | NC |
| miR-330 | −1.72 | −1.72 | NC | NC |
| miR-4449 | −1.76 | −1.94 | NC | NC |
| miR-491 | −2.63 | −2.41 | NC | NC |
| miR-550a-1/miR-550a-2 | −2.05 | −1.78 | NC | −3.07 |
| miR-671 | −1.73 | −1.85 | −1.81 | NC |
| miR-744 | −1.78 | −1.87 | NC | NC |
| miR-1180 | −2.14 | −1.78 | NC | NC |
| miR-1287 | −1.80 | −1.88 | NC | NC |
| miR-1296 | −1.83 | −2.83 | NC | −2.90 |
| miR-31 | NC | 3.68 | 1.88 | 4.39 |
| miR-100 | NC | 2.43 | 2.40 | 2.31 |
| miR-504 | NC | NC | 2.70 | 2.61 |
| miR-1269 | NC | NC | 2.41 | 2.10 |
| miR-3065 | NC | NC | 1.86 | 2.05 |
| miR-29b-1 | NC | NC | −2.11 | −2.22 |
| miR-342 | −1.77 | NC | −1.74 | −1.77 |
| miR-422a | NC | NC | −2.21 | −1.84 |
| miR-486 | −2.46 | NC | −1.88 | −1.80 |
| miR-4458 | NC | NC | −2.73 | −1.75 |
| miR-4534 | NC | NC | −2.42 | −3.51 |
| miR-4745 | NC | −1.80 | −2.74 | −3.74 |
aMicroRNAs (miRNAs) identified by the miRWalk database as being associated with a deregulated AKT pathway are shown in boldface type. bFold change (FC), corresponding to the ratio of the value for Res-Let or Res-Ana cells to that for MCF-7aro cells. Only probe sets with FC values superior to the cutoff selected (≥1.70 or less than or equal to −1.70) in the two independent cell culture replicates were considered to be differentially expressed. No change (NC) was defined as values −1.70 < FC <1.70.