Figure 2.

The complexity of microvascular remodelling spans multiple scales. (a) An image of a perfused microvascular network post-angiogenesis. PECAM labelling identifies all the vessels within the network and injected-dextran labelling indicates that even the newest formed vessels are patent. Scale bar, 200 μm. (b) A PECAM-positive capillary sprout perfused with dextran. Scale bar, 10 μm. (c) Example of CD11b-positive monocytes/macrophages along venules versus arterioles in an adult microvascular network. The differential adhesion of WBCs in vessel-specific locations further emphasizes the importance of cell dynamics in vessel- and network-level haemodynamics. Scale bar, 50 μm.