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. 2015 Jan 29;17(3):736–739. doi: 10.1021/acs.orglett.5b00015

Scheme 3. Scope of the One-Pot Sulfinylation Alkynylation.

Scheme 3

Reaction conditions: 0.20 mmol of 5 (1.0 equiv), 0.20 mmol of Mg (1.0 equiv), 0.20 mmol of DABSO (1.0 equiv), and THF (0.65 mL) were used for the first step. 0.24 mmol of TIPS-EBX 4a (1.2 equiv) and DMF (0.65 mL) were added for the second step. Isolated yield after purification on column chromatography is given.

Commercial Grignard reagent was used.

0.5 M organometallic reagent in THF.

R-Li was generated from the corresponding C–H bond with n-BuLi.

Commercial n-BuLi was used.