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Reduced trypanothione reductase from Leishmania infantum bound to NADPH and SbIII. SbIII is coordinated to the two redox-active catalytic cysteine residues (Cys52 and Cys57), Thr335 and His461 [389]. Reprinted with permission from Baiocco P, Colotti G, Franceschini S, Ilari A. 2009 J. Med. Chem. 52, 2603–2612. Copyright • 2009 American Chemical Society.
